In 2007, I revisited VTK and seeking for possibilities of using VTK with Cocoa framework in MacOSX. I thought that should be somehow straight forward since Osirix has been out for a while and it is using VTK doing graphics rendering. After digging deeper into Kitware website, I found that the CocoaVTK entry in VTK wiki is really helpful. Below are my step by step walkthrough to have VTK facilities into Xcode and had it work in Xcode, Cocoa, Interface Builder way.
Build VTK libraries
$port install cmake
$cd ~/dev
$tar xvzf vtk-5.0.2.tar.gz
$mkdir ~/dev/VTKBuild
$cd ~/dev/VTKBuild
$/opt/local/bin/cmake ../VTK
...
//Build classes using Carbon API.
VTK_USE_CARBON:BOOL=OFF
//Build classes using Cocoa API.
VTK_USE_COCOA:BOOL=ON
...
CMAKE_OSX_ARCHITECTURES:STRING=ppc;i386
CMAKE_OSX_SYSROOT:STRING=/Developer/SDKs/MacOSX10.4u.sdk/
You can download my CMackeCache.txt from here.
$cd ~/dev/VTKBin
$/opt/local/bin/cmake ../VTK
$make
And wait. Depending on your machine speed, the building process might take from 15 minutes to an hour. If you don't want to build it yourself and you trust my pre-built binary, you can download statically pre-built library files from here.
Config and use Xcode + Interface Builder
Add "vtk-lib" pointing to "~/dev/VTKBuild/bin"
Add "vtk-include" pointing to "~/dev/VTKBuild/include/vtk-5.0"
The config result should look like this (I renamed the "VTKBuild/bin" directory to "VTKBuild/lib" in pre-built library ZIP file):

BasicVTKView.h
BasicVTKView.mm
Drag a "Custom View" to your "Window", bring up its inspector, choose BasicVTKView in "Custom Class" drop down menu.


Notes
References