Recent data demonstrate that human papillomavirus (HPV)-associated oropharyngeal cancers (OPC) have discrete biology and clinical behavior as compared to HPV-negative OPC. We hypothesize that some phenotypic image features can be correlated to tumor biology in a non-invasive fashion. Some imaging features, specifically shape and intensity features can make a distinction between HPV-associated and HPV-negative OPC. Quantitative information from pretreatment imaging of intact tumor can give a better idea on tumor biology. Further studies are needed to validate the correlation between these radiomic biomarkers and other intrinsic tumor characteristics.

Support:
National Institutes of Health:
NCI-R01-CA214825, “SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer Treatment”
NCI-R01CA225190, “QuBBD: Precision E –Radiomics for Dynamic Big Head & Neck Cancer Data”

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Elhalawani, H., Mohamed, A., Volpe, V., Yang, P., Campbell, S., Granberry, R., Ger, R., Fave, X., Zhang, L., Marai, GE, Vock, DM, Canahuate, GM, Macking, D., Court, L., Gunn, GB, Rao, A., Fuller, CD, Predicting the HPV P16 Status of Oropharyngeal Cancer Patients Using Radiomics and an Ensemble of Random Forests, Radiology Society of North America meeting RSNA 2017, November 26th, 2017.