This multicenter (National Lung Screening Trial [NLST]) and catchment population–based (University of Illinois Health [UIH], urban and suburban Cook County) cross-sectional study used participants at risk of lung cancer with available lung computed tomography (CT) imaging and follow-up between the years 2015 and 2024. In all, 53,452 in NLST and 11,654 in UIH were included on the basis of age and tobacco use–based risk factors for lung cancer. Cohorts were used for training and testing of deep and machine learning models using clinical features alone or combined with CT image features (hybrid computer vision). An optimized seven-feature clinical model achieved receiver operating characteristic (ROC)-AUC values ranging from 0.64 to 0.67 in NLST and 0.60 to 0.65 in UIH cohorts across multiple years. Incorporation of imaging features to form a hybrid computer vision model significantly improved ROC-AUC values to 0.78-0.91 in NLST but deteriorated in UIH with ROC-AUC values of 0.68-0.80, attributable to Black participants where ROC-AUC values ranged from 0.63 to 0.72 across multiple years. Retraining the hybrid computer vision model by incorporating Black and other participants from the UIH cohort improved performance with ROC-AUC values of 0.70-0.87 in a held-out UIH test set.

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Salahudeen,A., Zakkar,A., Perwaiz,N., Harikrishnan,V., Zhong,W., Narra,V., Salahudeen,F., Zakkar,A., Perwaiz,N., Harikrishnan,V., Zhong,W., Yousef,F., Kim,D., Burrage-Burton,M., Lawal,A., Gadi,V., Korpics,M., Kim,S., Chen,Z., Khan,A., Molina,Y., Dai,Y., Marai,G., et al, A hybrid computer vision model to predict lung cancer in diverse populations, JCO Clinical Cancer Informatics, February 1st, 2026.